Breda, The Netherlands / Ghent, Belgium, June 17, 2015 - arGEN-X N.V. (Euronext Brussels: ARGX), a clinical-stage biopharmaceutical company focused on creating and developing differentiated therapeutic antibodies to treat cancer and severe autoimmune diseases, today presented preliminary results from an ongoing Phase I study of ARGX-110 in patients with T-cell lymphoma at the 13th International Conference on Malignant Lymphoma (Lugano, Switzerland; 17-20 June, 2015) in the ‘Novel Agents’ session.
ARGX-110 has been investigated in a Phase I patient cohort with advanced lymphomas expressing CD70. Of eight patients with relapsed/refractory T-cell lymphomas in this cohort, a biologic response was observed in three patients: in two patients with cutaneous T-cell lymphoma (Sézary syndrome), one of which had stable disease for more than six months; and in one patient with angioimmunoblastic T-cell lymphoma.
“Our strategy is to use this Phase I study to identify orphan cancer indications where ARGX-110 shows clinical benefit and then to enrich our study population with these patients to establish clinical proof of efficacy,” said Tim Van Hauwermeiren, Chief Executive Officer of arGEN-X. “The results we have seen to-date with ARGX-110 in relapsed/refractory CD70+ T-cell lymphoma patients provides compelling evidence to support its further development in these indications.”
An oral presentation of the results entitled “ARGX-110, a novel monoclonal antibody targeting CD70, is associated with biological activity in patients with relapsed/refractory T-cell lymphomas” was presented by Dr. Marie Maerevoet from the Institut Jules Bordet (Brussels, Belgium).
About ARGX-110
ARGX-110 is a first-in-class monoclonal antibody that potently blocks CD70-induced tumor proliferation and tumor escape from immune surveillance. In addition, the POTELLIGENT®-enhanced antibody-dependent cellular cytotoxicity (ADCC) of ARGX-110 enables selective destruction of CD70-positive tumor cells. CD70 is overexpressed in the majority of cancer patients tested to date. In the initial dose-escalation of the Phase I study, ARGX-110 demonstrated a favorable safety profile with no dose-limiting toxicities seen in the 26 patients treated. ARGX-110 was well tolerated at doses between 0.1 to 10 mg/kg administered intravenously once every three weeks, and the maximum tolerated dose was not reached.
About arGEN-X
arGEN-X (ARGX) combines the diversity of the llama immune system with antibody engineering to advance a clinical pipeline to treat patients with cancer and autoimmune diseases. Our platforms allow us to unlock novel and complex targets and develop antibody-based drugs designed for longer duration of effect and greater efficacy. The strength of our team, our deep understanding of the biology, and our committed collaborations with industry leaders contribute to the success of our journey.
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